PHAR 616 IPC 3-Endocrine

The concepts of pathophysiology, medicinal chemistry, pharmacology, and pharmacotherapy are applied to the management of patients with endocrinologic disorders such as diabetes mellitus, thyroid disorders, adrenal and pituitary gland disorders. The course will introduce first the pathophysiology of a particular endocrine disorder, and then will present the respective drugs or drug classes emphasizing on their structure-activity relationship, mechanisms of action, pharmacokinetics, and effects on various organ systems, toxicity profiles, contraindication, and drug-drug interactions. Pharmacotherapeutics will be taught in a sequential and integrative manner to tie in the knowledge and concepts from medicinal chemistry coupled with the pharmacology of the drugs used in the corresponding disease and the pathophysiology and therapeutic principles in clinical practice. The clinical presentation, course of illness, assessment of patient, and epidemiology of disease as well as treatment and preventative measures using pharmacologic and non-pharmacologic approaches will be reviewed. This will enable students to relate the knowledge from both basic sciences and clinical sciences and to develop rational therapeutic recommendations to various healthcare providers and patients.